Speaker
Rob Edwards
(Flinders University)
Description
We resolved hundreds of bacteriophage genomes into distinct structural components through high-resolution assembly graph analysis of metagenomic datasets. We uncovered extensive genomic variation and quasispecies dynamics. Our analyses revealed a striking anti-correlation between genome plasticity and dominance, suggesting that phage populations balance genetic variability and selective advantage. We provide new insights into how phage populations diversify and adapt by integrating assembly graphs, gene annotations, and ANI comparisons across clinical (IBD) and environmental (Tara Oceans) samples.
