Name: Modelling Resistance Evolution – Theoretical Methodology Symposium
Start: 2023-04-26T08:45:00+02:00
End: 2023-04-28T19:00:00+02:00
Location: MPI for Evolutionary Biology

Modelling Resistance Evolution – Theoretical Methodology Symposium

from Wednesday, 26 April 2023 (08:45) to Friday, 28 April 2023 (19:00)

Monday, 24 April 2023
Tuesday, 25 April 2023
Wednesday, 26 April 2023

08:45 Welcome
Welcome
08:45 - 09:00
Room: Lecture Hall
09:00 Hildegard Uecker
Hildegard Uecker
09:00 - 10:00
Room: Lecture Hall
Contributions

09:00 Stochastic models of resistance evolution - Hildegard Uecker (MPI for Evolutionary Biology)
10:00 Coffee break
Coffee break
10:00 - 10:30
10:30 Session 1
Session 1
10:30 - 12:30
Room: Lecture Hall
Contributions

10:30 The importance of persistence for the evolvability of antibiotic resistance - Giorgio Boccarella (KU Leuven)

11:00 Mathematical models of collective antibiotic tolerance - Pierre Lafont (University of Edinburgh)

11:30 Evolution of multidrug resistance from plasmid-mediated heterozygosity - Ian Dewan (MPI for Evolutionary Biology)

12:00 Memory and Hysteresis in the adaptive evolution of bacterial resistance in environments of varying antibiotic concentration - Muhittin Mungan (University of Cologne)
12:30 Group picture
Group picture
12:30 - 12:35

12:35 Lunch break
Lunch break
12:35 - 13:30
13:30 Jasmine Foo
Jasmine Foo
13:30 - 14:30
Room: Lecture Hall
Contributions

13:30 Computational methods for inferring tumor evolution and heterogeneity - Jasmine Foo (University of Minnesota)
14:30 Coffee break
Coffee break
14:30 - 15:00
15:00 Session 2
Session 2
15:00 - 16:00
Room: Lecture Hall
Contributions

15:00 Multi-step Resistance Evolution in Compact Populations - Jona Kayser (MPZ für Physik und Medizin & MPI for the Science of Light)

15:30 What to target in evolving populations - population size, growth or survival? - Michael Raatz (MPI for Evolutionary Biology)
16:00 Opening
Opening
16:00 - 16:30
Room: Lecture Hall
Contributions

16:00 Ecological vs. game theoretical models for interaction (opening to method sessions) - Arne Traulsen (MPI for Evolutionary Biology)
16:30 Session 1
Session 1
16:30 - 18:00
Room: Lecture Hall

18:00 Dinner
Dinner
18:00 - 19:00
Room: Lecture Hall

19:00 Discussion
Discussion
19:00 - 20:00
Room: Lecture Hall
Thursday, 27 April 2023
09:00 Helen Alexander
Helen Alexander
09:00 - 10:00
Room: Lecture Hall
Contributions

09:00 Stochastic emergence of drug resistance in variable environments - Helen Alexander (University of Edinburgh)
10:00 Coffee Break
Coffee Break
10:00 - 10:30
Room: Lecture Hall
10:30 Session 3
Session 3
10:30 - 12:30
Room: Lecture Hall
Contributions

10:30 Model-based design of innovative treatment strategies to suppress antimicrobial resistance using collateral sensitivity - Linda Aulin (Leiden Academic Centre for Drug Research, Leiden University, Leiden & Clinical Pharmacy and Biomedicine, Freie Universität Berlin)

11:00 Fitness seascapes reveal heterogeneous mutant selection windows in clinically-relevant pharmacokinetic models - Eshan King (Case Western Reserve University School of Medicine)

11:30 Modeling Stress-Induced Responses in Bacterial and Cancer Therapeutic Resistance - Anuraag Bukkuri (Moffitt Cancer Center and Lund University)

12:00 Mechanisms of non-genetic resistance to cancer therapy - Irina Kareva (Northeastern University)
12:30 Lunch
Lunch
12:30 - 13:30
Room: Lecture Hall
13:30 Jacob Scott
Jacob Scott
13:30 - 14:30
Room: Lecture Hall
Contributions

13:30 Perturbing the ecological forces underlying drug resistance in cancer: towards evolutionary therapy - Jacob Scott (Cleveland Clinic)
14:30 Coffee Break
Coffee Break
14:30 - 15:00
Room: Lecture Hall

15:00 Session 2
Session 2
15:00 - 17:00
Room: Lecture Hall

17:00 Fingerfood
Fingerfood
17:00 - 18:00
Room: Lecture Hall

18:00

18:00 - 19:00
Room: Lecture Hall
Friday, 28 April 2023
09:00 Barbora Trubenová
Barbora Trubenová
09:00 - 10:00
Room: Lecture Hall
Contributions

09:00 Modeling drug resistance in bacterial biofilms and parasitic worms - Barbora Trubenová (ETH Zurich)
10:00 Coffee Break
Coffee Break
10:00 - 10:30
Room: Lecture Hall
10:30 Session 4
Session 4
10:30 - 12:30
Room: Lecture Hall
Contributions

10:30 Competing effects of mutation bias and selection on resistance evolution - Joachim Krug (Institute for Biological Physics, University of Cologne)

11:00 Learning and predicting the pathways of AMR evolution with hypercubic inference - Jessica Renz (University of Bergen)

11:30 Modeling selection for evolvability in the evolution of cancer therapy resistance - Malgorzata Weh (H. Lee Moffitt Cancer Center & University of South Florida)

12:00 Repeatability of antibiotic resistance evolution for heavy-tailed distributions of fitness effects - Suman G Das (Institute for Biophysics, University of Cologne)
12:30 Lunch
Lunch
12:30 - 13:30
Room: Lecture Hall
13:30 Tobias Bollenbach
Tobias Bollenbach
13:30 - 14:30
Room: Lecture Hall
Contributions

13:30 Quantitative descriptions of bacterial responses to antibiotics - Tobias Bollenbach (University of Cologne)
14:30 Coffee Break
Coffee Break
14:30 - 15:00
Room: Lecture Hall

15:00 Session 3
Session 3
15:00 - 17:00
Room: Lecture Hall

17:00 Closing Remarks
Closing Remarks
17:00 - 18:00
Room: Lecture Hall

18:00 Barbecue at the institute
Barbecue at the institute
18:00 - 19:00
Room: Lecture Hall