Name: Modelling Resistance Evolution – Theoretical Methodology Symposium
Start: 2023-04-26T08:45:00+02:00
End: 2023-04-28T19:00:00+02:00
Location: MPI for Evolutionary Biology

Modelling Resistance Evolution – Theoretical Methodology Symposium

from Wednesday, April 26, 2023 (8:45 AM) to Friday, April 28, 2023 (7:00 PM)

Monday, April 24, 2023
Tuesday, April 25, 2023
Wednesday, April 26, 2023

8:45 AM Welcome
Welcome
8:45 AM - 9:00 AM
Room: Lecture Hall
9:00 AM Hildegard Uecker
Hildegard Uecker
9:00 AM - 10:00 AM
Room: Lecture Hall
Contributions

9:00 AM Stochastic models of resistance evolution - Hildegard Uecker (MPI for Evolutionary Biology)
10:00 AM Coffee break
Coffee break
10:00 AM - 10:30 AM
10:30 AM Session 1
Session 1
10:30 AM - 12:30 PM
Room: Lecture Hall
Contributions

10:30 AM The importance of persistence for the evolvability of antibiotic resistance - Giorgio Boccarella (KU Leuven)

11:00 AM Mathematical models of collective antibiotic tolerance - Pierre Lafont (University of Edinburgh)

11:30 AM Evolution of multidrug resistance from plasmid-mediated heterozygosity - Ian Dewan (MPI for Evolutionary Biology)

12:00 PM Memory and Hysteresis in the adaptive evolution of bacterial resistance in environments of varying antibiotic concentration - Muhittin Mungan (University of Cologne)
12:30 PM Group picture
Group picture
12:30 PM - 12:35 PM

12:35 PM Lunch break
Lunch break
12:35 PM - 1:30 PM
1:30 PM Jasmine Foo
Jasmine Foo
1:30 PM - 2:30 PM
Room: Lecture Hall
Contributions

1:30 PM Computational methods for inferring tumor evolution and heterogeneity - Jasmine Foo (University of Minnesota)
2:30 PM Coffee break
Coffee break
2:30 PM - 3:00 PM
3:00 PM Session 2
Session 2
3:00 PM - 4:00 PM
Room: Lecture Hall
Contributions

3:00 PM Multi-step Resistance Evolution in Compact Populations - Jona Kayser (MPZ für Physik und Medizin & MPI for the Science of Light)

3:30 PM What to target in evolving populations - population size, growth or survival? - Michael Raatz (MPI for Evolutionary Biology)
4:00 PM Opening
Opening
4:00 PM - 4:30 PM
Room: Lecture Hall
Contributions

4:00 PM Ecological vs. game theoretical models for interaction (opening to method sessions) - Arne Traulsen (MPI for Evolutionary Biology)
4:30 PM Session 1
Session 1
4:30 PM - 6:00 PM
Room: Lecture Hall

6:00 PM Dinner
Dinner
6:00 PM - 7:00 PM
Room: Lecture Hall

7:00 PM Discussion
Discussion
7:00 PM - 8:00 PM
Room: Lecture Hall
Thursday, April 27, 2023
9:00 AM Helen Alexander
Helen Alexander
9:00 AM - 10:00 AM
Room: Lecture Hall
Contributions

9:00 AM Stochastic emergence of drug resistance in variable environments - Helen Alexander (University of Edinburgh)
10:00 AM Coffee Break
Coffee Break
10:00 AM - 10:30 AM
Room: Lecture Hall
10:30 AM Session 3
Session 3
10:30 AM - 12:30 PM
Room: Lecture Hall
Contributions

10:30 AM Model-based design of innovative treatment strategies to suppress antimicrobial resistance using collateral sensitivity - Linda Aulin (Leiden Academic Centre for Drug Research, Leiden University, Leiden & Clinical Pharmacy and Biomedicine, Freie Universität Berlin)

11:00 AM Fitness seascapes reveal heterogeneous mutant selection windows in clinically-relevant pharmacokinetic models - Eshan King (Case Western Reserve University School of Medicine)

11:30 AM Modeling Stress-Induced Responses in Bacterial and Cancer Therapeutic Resistance - Anuraag Bukkuri (Moffitt Cancer Center and Lund University)

12:00 PM Mechanisms of non-genetic resistance to cancer therapy - Irina Kareva (Northeastern University)
12:30 PM Lunch
Lunch
12:30 PM - 1:30 PM
Room: Lecture Hall
1:30 PM Jacob Scott
Jacob Scott
1:30 PM - 2:30 PM
Room: Lecture Hall
Contributions

1:30 PM Perturbing the ecological forces underlying drug resistance in cancer: towards evolutionary therapy - Jacob Scott (Cleveland Clinic)
2:30 PM Coffee Break
Coffee Break
2:30 PM - 3:00 PM
Room: Lecture Hall

3:00 PM Session 2
Session 2
3:00 PM - 5:00 PM
Room: Lecture Hall

5:00 PM Fingerfood
Fingerfood
5:00 PM - 6:00 PM
Room: Lecture Hall

6:00 PM

6:00 PM - 7:00 PM
Room: Lecture Hall
Friday, April 28, 2023
9:00 AM Barbora Trubenová
Barbora Trubenová
9:00 AM - 10:00 AM
Room: Lecture Hall
Contributions

9:00 AM Modeling drug resistance in bacterial biofilms and parasitic worms - Barbora Trubenová (ETH Zurich)
10:00 AM Coffee Break
Coffee Break
10:00 AM - 10:30 AM
Room: Lecture Hall
10:30 AM Session 4
Session 4
10:30 AM - 12:30 PM
Room: Lecture Hall
Contributions

10:30 AM Competing effects of mutation bias and selection on resistance evolution - Joachim Krug (Institute for Biological Physics, University of Cologne)

11:00 AM Learning and predicting the pathways of AMR evolution with hypercubic inference - Jessica Renz (University of Bergen)

11:30 AM Modeling selection for evolvability in the evolution of cancer therapy resistance - Malgorzata Weh (H. Lee Moffitt Cancer Center & University of South Florida)

12:00 PM Repeatability of antibiotic resistance evolution for heavy-tailed distributions of fitness effects - Suman G Das (Institute for Biophysics, University of Cologne)
12:30 PM Lunch
Lunch
12:30 PM - 1:30 PM
Room: Lecture Hall
1:30 PM Tobias Bollenbach
Tobias Bollenbach
1:30 PM - 2:30 PM
Room: Lecture Hall
Contributions

1:30 PM Quantitative descriptions of bacterial responses to antibiotics - Tobias Bollenbach (University of Cologne)
2:30 PM Coffee Break
Coffee Break
2:30 PM - 3:00 PM
Room: Lecture Hall

3:00 PM Session 3
Session 3
3:00 PM - 5:00 PM
Room: Lecture Hall

5:00 PM Closing Remarks
Closing Remarks
5:00 PM - 6:00 PM
Room: Lecture Hall

6:00 PM Barbecue at the institute
Barbecue at the institute
6:00 PM - 7:00 PM
Room: Lecture Hall

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