Mathematical Models of Evolutionary Rescue

Session

Posters

Jun 6, 2023, 10:30 AM

Description

Please find the poster abstracts here, sort for posters: https://workshops.evolbio.mpg.de/event/82/contributions/

7. A multitype branching process model of herbicide resistance adaptation

Dana Lauenroth (MPI for Evolutionary Biology)

Modern agriculture faces the problem of meeting the rapidly increasing demand for food in a growing world population while minimising the environmental impacts. Weeds are a major threat to crop production, causing the highest yield losses among pests. Since the late 1960s, conventional agriculture has primarily relied on herbicides for controlling weeds. This overreliance on herbicides has led...

10. Emerging from regulation – How to target evolving populations?

Michael Raatz (MPI for Evolutionary Biology)

Populations of microbial pathogens or cancer cells possess enormous adaptive potential that allows them to emerge from homeostatic regulations for example by the immune system. From a reductionistic viewpoint, the fundamental processes in such populations are replication, mutation and death. Using traits to represent these processes, the emergence from homeostatic regulation can be understood...

5. Evolutionary fate of a finite population

Archana Devi (Arizona State University, USA )

Evolution is a heritable change in the characteristics of the population over time and adaptation is the evolutionary process by which a population survives in its environment. Stochastic fluctuations due to finite population size can alter the fate of the population and therefore, it is crucial to understand the dynamics of adaptation in a finite population. We explore the evolution of a...

8. Evolutionary rescue via niche construction

Alexander Longcamp (Virginia Tech )

We analytically approximated the probability of evolutionary rescue via a mutation that allows carriers to perform positive niche construction, whereby an unfavorable, novel habitat is converted to a favorable habitat at a fecundity cost. We assumed that mutants are in competition with non-niche-constructing wild types and that both types benefit from the reproductive habitats constructed by...

6. Male harm offsets the demographic benefits of good genes

Ewan Flintham (University of Lausanne)

Over the last three decades, there has been mounting interest in the population level consequences of sexual selection. In particular, such selection has been argued to benefit populations by decreasing the frequency of deleterious alleles (reducing mutation load) and expediting adaptation to new environmental conditions. This occurs because male mating traits typically show strong...

4. Population Epigenetics of Evolutionary Rescue

Puneeth Deraje (University of Toronto )

Surviving changes in the environment by rapid adaptation, termed evolutionary rescue, is central to the fields of conservation, antibiotic resistance and agriculture. Conventionally, evolutionary rescue studies assume a genetic basis of adaptation. However, there is growing evidence for transgenerational epigenetic effects that can influence evolutionary dynamics and consequently the...

1. Stochastic dynamics of cancer relapse in hematologic malignancies

Philipp Altrock (MPI for Evolutionary Biology)

In hematologic cancers, the initial response to therapy can be observed via temporal changes in tumor burden or approximate measures of tumor burden during treatment. Once the cancer cell population is small, further disease evolution is dominated by underlying stochastic disease kinetics. Many treatments evoke an initial response and tumor decline, but hidden (or difficult to detect) cancer...

9. The optimal dosing strategy for antibiotic combinations

Christin Nyhoegen (MPI for Evolutionary Biology)

The evolution of antimicrobial resistance in bacteria poses a major challenge for patient treatment worldwide. One option to reduce the risk of the undesired evolutionary rescue during treatment is to increase the genetic barrier to resistance, which can, for example, be achieved by increasing the number of drugs applied. With multiple drugs in combination, applying the different drugs at the...

2. The role of stochasticity in the interplay between bottleneck size and antibiotic-induced selection in resistance evolution

Ernesto Berríos-Caro (MPI for Evolutionary Biology)

Bacterial populations face bottlenecks during infection of host populations, caused by factors such as transmission of pathogens, host immune response, and antibiotic treatment. Bottlenecks can increase the influence of random effects during bacterial evolution and directly affect the diversity of resistance alleles. Despite the importance of bottlenecks in resistance evolution, their role in...