Evolutionary Biology meets the Antibiotic Crisis


The current spread of antibiotic resistance poses a dramatic threat to global health. We are thus in urgent need of novel treatment strategies. As the evolutionary potential of pathogens is part of the problem, sustainable strategies should take account of the selection dynamics underlying the emergence and rise in resistance. However, most public health measures do not yet address pathogen evolution. The aim of the symposium and workshop is therefore to strengthen the exchange between fundamental research in evolutionary biology on antibiotic resistance and medical practice. How can medical challenges be approached by evolutionary biologists in a sensible way? And how can insights from evolutionary biology be implemented in practice? The workshop will therefore bring together physicians with expertise in antibiotic therapy, experimental evolutionary biologists, and modelers. The first part consists of a symposium with open registration (available spots limited to 20). In the second part, invited participants will form discussion groups to develop novel ideas concerning the above questions.

  • Aditi Batra
  • Agnes Piecyk
  • Alex Hall
  • Alexandra Tietze
  • Alexandro Rodriguez-Rojas
  • Andrew Farr
  • Anette Friedrichs
  • Anna Tabea Löblein
  • Annegret Krenz-Weinreich
  • Annelies Zinkernagel
  • Annette Moter
  • Arne Traulsen
  • Arpita Nath
  • Barbara Hasse
  • Carmen Senin
  • Christoph Lange
  • Espen Groth
  • Florence Bansept
  • Francy Johanna Perez LLanos
  • Guy Reeves
  • Hildegard Uecker
  • Hinrich Schulenburg
  • Ingrid Bobis
  • Jan Rupp
  • Jana Huisman
  • Jelena Rajkov
  • Jens Rolff
  • Johana Fajardo Castro
  • João Botelho
  • Kim Wagner
  • Leif Tüffers
  • Lina Upterworth
  • Lindsay Sonnenkalb
  • Loukas Theodosiou
  • Luka Opasic
  • Marcus Fulde
  • Mario Santer
  • Matthias Merker
  • Maxime Godfroid
  • Michael Raatz
  • Michael Sieber
  • Niels Mahrt
  • Roland Regös
  • Rosa Haghiri Limoudehi
  • Sebastian Bonhoeffer
  • shpetime jonuzi
  • Stefan Niemann
  • Thomas Bahmer
  • Uwe Rösler
    • 12:30 13:00
      Get-Together and Welcome 30m
    • 13:00 15:00
      Day 1: Session 1
      • 13:00
        Resistance evolution against antimicrobial peptides 30m
        Speaker: Jens Rolff (FU Berlin)
      • 13:30
        Precision Medicine prevents evolving drug resistance in M. tubercolosis 30m
        Speaker: Christoph Lange (Research Center Borstel)
      • 14:00
        Pharmacodynamic inoculum effect from the perspective of bacterial population modeling 30m
        Speaker: Roland Regös (ETH Zürich)
      • 14:30
        tba 30m
        Speaker: Annelies Zinkernagel (University Hospital Zürich)
    • 15:00 15:30
      Coffee Break 30m
    • 15:30 17:00
      Day 1: Session 2
      • 15:30
        Optimal antibiotic dosing: Insights from theory and experiments 30m
        Speaker: Hildegard Uecker (MPI for Evolutionary Biology)
      • 16:00
        Antimicrobial Resistance at the animal-human-environment interface 15m
        Speaker: Uwe Rösler (FU Berlin)
      • 16:15
        tba 15m
        Speaker: Marcus Fulde (FU Berlin)
      • 16:30
        Lessons from the Real World Scenario: Fighting Pseudomonas Aeruginosa in Cystic Fibrosis (CF) 30m
        Speaker: Ingrid Bobis
    • 17:00 17:30
      Coffee Break 30m
    • 17:30 18:30
      Day 1: Session 3
      • 17:30
        Antibiotic treatment strategies and their clinical implementation 30m
        Speaker: Anette Friedrichs (UKSH)
      • 18:00
        Rapid in vivo resistance evolution during antibiotic therapy of Pseudomonas aeruginosa 30m
        Speaker: Leif Tüffers (Uni Kiel)
    • 18:30 19:15
      Aperitif 45m
    • 09:00 10:30
      Day 2: Session 1
      • 09:00
        Sequential therapy as a strategyy to minimize resistance evolution 30m
        Speaker: Hinrich Schulenburg (MPI for Evolutionary Biology)
      • 09:30
        Antibiotic cycling or mixing - is there a clinical way to avoid antimicrobial resistance? 30m
        Speaker: Jan Rupp (UKSH)
      • 10:00
        Resistance evolution of E.coli in populations and communities 30m
        Speaker: Alex Hall (ETH Zürich)
    • 10:30 11:00
      Coffee Break 30m
    • 11:00 13:00
      Day 2: Session 2
      • 11:00
        Pathogen-based precision medicine for drug-resistant tuberculosis 30m
        Speaker: Stefan Niemann (Research Center Borstel)
      • 11:30
        Guideline-adapted diagnostics for cystic fibrosis patients 30m
        Speaker: Annette Krenz-Weinreich (Sana-Kliniken Lübeck und Ost-Holstein)
      • 12:00
        How dead is dead in biofilms? 30m
        Speaker: Annette Moter (Charité Berlin)
      • 12:30
        In vitro epidemiology: Comparison of cycling, mixing and combination therapy 30m
        Speaker: Sebastian Bonhoeffer (ETH Zürich)
    • 13:00 14:00
      Lunch 1h
    • 14:00 18:00
      Discussions: Invited participants
    • 09:00 13:00
      Discussions: Invited Participants