Modeling Diversity in Cancer And Virus Evolution

Europe/Berlin
Lecture Hall (MPI for Evolutionary Biology)

Lecture Hall

MPI for Evolutionary Biology

August-Thienemann-Str 2 Plön
Description

The evolutionary dynamics of complex human diseases pose unique challenges, such as predicting how therapy alters the evolution of an HIV infection, or how chemotherapy changes a solid tumor’s cellular diversity and aggressiveness. Using experimental, computational and mathematical tools, we seek for patterns and mechanisms that govern the course of disease, before, during and after treatment. Measuring and understanding diversity of microbes and cells, e.g. during viral infections or during cancer progression, have proven to be important for predicting disease evolution. With this workshop we will bring together leading experts from both virus evolution and cancer evolution to talk about recent theoretical, clinical an experimental advances to understanding cellular diversity and evolution. We hope to inspire and facilitate a discourse that can lead to new perspectives and research avenues. 

Confirmed invited speakers are Alison Hill (Harvard University), Ian Tomlinson (University of Birmingham), Trevor Graham (University of London), Tibor Antal (University of Edinburgh), Alexander Anderson (Moffitt Cancer Center), and Roland Regös (ETH Zurich).

Scientific organization: Philipp Altrock (Moffitt Cancer Center) and Arne Traulsen (MPI for Evolutionary Biology).

Participants
  • Alexander Anderson
  • Alison Hill
  • Andriy Marusyk
  • Arne Traulsen
  • Caroline Watson
  • Chaitanya Gokhale
  • Charlotte Flueh
  • Claus-C. Glüer
  • Daniel Nichol
  • Emma Wagner
  • Frederic Bertels
  • Ian Tomlinson
  • Jacob Scott
  • Jamie Blundell
  • Jatin Arora
  • Laura Hindersin
  • Luis Zapata
  • Luka Opasic
  • Maria Bargues Ribera
  • Mark Robertson-Tessi
  • Marvin Böttcher
  • Meghan Ferrall-Fairbanks
  • Michael Nicholson
  • Nikhil Krishnan
  • Philipp Altrock
  • Pirmin Schlicke
  • Roland Regös
  • Sanjay Tiwari
  • Tibor Antal
  • Trevor Graham
  • Vandana Revathi Venkateswaran
  • Wolfram Moebius
    • 16:45 17:00
      Welcome & Evening Lecture: Welcome Lecture Hall

      Lecture Hall

      MPI for Evolutionary Biology

      August-Thienemann-Str 2 Plön
    • 17:00 18:00
      Welcome & Evening Lecture: Keynote: Alison Hill Lecture Hall

      Lecture Hall

      MPI for Evolutionary Biology

      August-Thienemann-Str 2 Plön
    • 18:00 20:00
      Get Together 2h Cafeteria

      Cafeteria

    • 09:00 10:30
      Session 1 Lecture Hall

      Lecture Hall

      MPI for Evolutionary Biology

      August-Thienemann-Str 2 Plön
      • 09:00
        The evolutionary history of colorectal cancers 50m
        Speaker: Ian Tomlinson
      • 09:50
        Learning and perturbing the evolutionary mechanisms driving therapeutic resistance in cancer 40m
        Speaker: Jacob Scott
    • 10:30 11:00
      Coffee Break 30m Lecture Hall

      Lecture Hall

      MPI for Evolutionary Biology

      August-Thienemann-Str 2 Plön
    • 11:00 12:30
      Session 2 Lecture Hall

      Lecture Hall

      MPI for Evolutionary Biology

      August-Thienemann-Str 2 Plön
      • 11:00
        Personalized adaptive therapies for metastatic melanoma: A phase I approach 50m
        Speaker: Alexander R. A. Anderson
      • 11:50
        Inferring clonal mutations from a spatial computational model of intratumour heterogeneity 20m
        Speaker: Luka Opasic
      • 12:10
        Experimental and Mathematical Modelling of Collateral Sensitivity in Heterogeneous Cancer Populations 20m
        Speaker: Daniel Nichol
    • 12:30 14:00
      Lunch Break 1h 30m Cafeteria

      Cafeteria

    • 14:00 15:20
      Session 3 Lecture Hall

      Lecture Hall

      MPI for Evolutionary Biology

      August-Thienemann-Str 2 Plön
      • 14:00
        Evolution of Competing Diversities: Tumor vs. Immune 20m
        Speaker: Mark Robertson-Tessi
      • 14:20
        A roadmap to precision medicine in breast cancer bone metastases 20m
        Speaker: Sanjay Tiwari
      • 14:40
        Evolution of resistance to ALK targeting therapies in NSCLC 40m
        Speaker: Andriy Marusyk
    • 15:20 15:50
      Coffee Break 30m Lecture Hall

      Lecture Hall

      MPI for Evolutionary Biology

      August-Thienemann-Str 2 Plön
    • 15:50 17:25
      Session 4 Lecture Hall

      Lecture Hall

      MPI for Evolutionary Biology

      August-Thienemann-Str 2 Plön
      • 15:50
        Convergence in viral populations 40m
        Speaker: Frederic Bertels
      • 16:30
        Exploring evolutionary trajectories of populations subjected to sequences of drugs in vitro 25m
        Speaker: Nikhil Krishnan
      • 16:55
        In-depth characterization of a hallmark for balancing selection: HLA heterozygote advantage against HIV-1 30m
        Speaker: Jatin Arora
    • 18:00 19:00
      Dinner 1h Cafeteria

      Cafeteria

    • 19:00 20:00
      Afterwards: Discussions Lecture Hall

      Lecture Hall

      MPI for Evolutionary Biology

      August-Thienemann-Str 2 Plön
    • 09:00 10:30
      Session 5 Lecture Hall

      Lecture Hall

      MPI for Evolutionary Biology

      August-Thienemann-Str 2 Plön
      • 09:00
        Estimating the mutational fitness effects distribution during early HIV infection 50m
        Speaker: Roland Regös
      • 09:50
        Detection of Immune-mediated negative selection using dN/dS 20m
        Speaker: Luis Zapata
      • 10:10
        Pathways to resistance in growing populations over fitness valleys 20m
        Speaker: Michael Nicholson
    • 10:30 11:00
      Coffee Break 30m Lecture Hall

      Lecture Hall

      MPI for Evolutionary Biology

      August-Thienemann-Str 2 Plön
    • 11:00 12:10
      Session 6 Lecture Hall

      Lecture Hall

      MPI for Evolutionary Biology

      August-Thienemann-Str 2 Plön
      • 11:00
        Measuring evolutionary dynamics of human cancers from genomic data 50m
        Speaker: Trevor Graham
      • 11:50
        Stopping treatment of CML in virtual patients 20m
        Speaker: Marvin Böttcher
    • 12:10 13:40
      Lunch Break 1h 30m Cafeteria

      Cafeteria

    • 13:40 15:10
      Session 7 Lecture Hall

      Lecture Hall

      MPI for Evolutionary Biology

      August-Thienemann-Str 2 Plön
      • 13:40
        Evolution of Clonal Heterogeneity in Chronic Myelomonocytic Leukemia 40m
        Speaker: Meghan Ferrall-Fairbanks
      • 14:20
        Immunogenicity and tumor dormancy in brain metastases: comparison of central and peripheral markers of tumor dormancy in relation to NKG2DL expression 25m
        Speaker: Charlotte Flueh
      • 14:45
        Front dynamics and evolution associated with spatial spread 25m
        Speaker: Wolfram Moebius
    • 15:30 16:00
      Optional: Tour of the institute 30m Lecture Hall

      Lecture Hall

      MPI for Evolutionary Biology

      August-Thienemann-Str 2 Plön
    • 16:15 18:15
      Boat Trip, Dinner & Discussions 2h Landgasthaus Kasch

      Landgasthaus Kasch

      Timmdorf
    • 18:15 19:15
      Discussion: What can cancer evolution learn from virus dynamics? What can virus evolution learn from cancer dynamics? 1h Lecture Hall

      Lecture Hall

      MPI for Evolutionary Biology

      August-Thienemann-Str 2 Plön
    • 09:00 10:30
      Session 8 Lecture Hall

      Lecture Hall

      MPI for Evolutionary Biology

      August-Thienemann-Str 2 Plön
      • 09:00
        Keynote: Tibor Antal 50m
        Speaker: Tibor Antal
      • 09:50
        Discussion: What can cancer evolution learn from virus dynamics? What can virus evolution learn from cancer dynamics? 40m
    • 10:30 11:00
      Coffee Break 30m Lecture Hall

      Lecture Hall

      MPI for Evolutionary Biology

      August-Thienemann-Str 2 Plön
    • 11:00 12:00
      Session 9 Lecture Hall

      Lecture Hall

      MPI for Evolutionary Biology

      August-Thienemann-Str 2 Plön
      • 11:00
        The dynamics of adaptive genetic diversity during the early stages of clonal evolution 20m
        Speaker: Jamie Blundell
      • 11:20
        How do cellular selection and diversity contribute to leukemic progression? Seeking answers using computational and mathematical analyses 40m
        Speaker: Philipp Altrock
    • 12:00 12:15
      Farewell 15m Lecture Hall

      Lecture Hall

      MPI for Evolutionary Biology

      August-Thienemann-Str 2 Plön
      Speakers: Arne Traulsen, Philipp Altrock